Clinical Guidelines


Cervical cancer screening

Management of discordant colposcopic impression, histopathology and referral LBC prediction


GUIDELINE UPDATES - This guideline was last updated 7/1/2022

Unresolved issues

There is currently insufficient high-level evidence to guide the management of discrepancies between cytological findings and colposcopic impression in women who have positive oncogenic HPV test results, or who have pLSIL/LSIL and Type 3 TZ colposcopy. These consensus-based recommendations and practice points are considered conservative and offer a safe approach, but this may require review as future research results become available.

Future research priorities

To determine optimal management, evidence is needed from:

  • prospective audits of management strategies of large cohorts of women who have positive oncogenic HPV test results with discordant cytology and colposcopic findings
  • randomised controlled trials or longitudinal studies comparing management strategies for women with a positive oncogenic HPV test result, who have normal cytology or pLSIL/LSIL, and Type 3 TZ colposcopy.


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WEBSITE UPDATES - This website was last updated 7/1/2022

Cancer Council would like to acknowledge the traditional custodians of the land on which we live and work. We would also like to pay respect to the elders past and present and extend that respect to all other Aboriginal people.
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